Tae Hyun Ryu

POSTDOCTORAL FELLOW

Ph.D. in Molecular Biology, University of Southern California

taehyun_ryu@hms.harvard.edu

BACKGROUND

I received my bachelor’s degree in Biology from Brandeis University, where I completed my honors thesis with Dr. Jim Haber. During my undergraduate research, I studied the role of resection and DNA helicases in cell’s choice between gene conversion and single stranded annealing during double strand break (DSB) repair using Saccharomyces cerevisiae.

To continue pursing my interest in DNA repair research, I joined Dr. Irene Chiolo’s lab at the University of Southern California, where I completed my Ph.D work. During my Ph.D, my study focused on understanding the DNA repair mechanism in heterochromatin. I discovered the heterochromatic repair sites move to the nuclear periphery to continue homologous recombination repair. Also, I demonstrated that SUMOylation is important for protecting heterochromatic DSBs from aberrant recombination.


RESEARCH

I am interested in understanding the role of ultraconserved elements (UCEs) in maintaining genome stability in human cells. Also, I am interested in developing multiplexed 3D genome imaging and sequencing technologies.


PUBLICATIONS

Caridi C.*, D’Agostino C.*, Ryu T., Zapotoczny G., Delabaere L., Li X., Khodaverdian V., Amaral N., Lin E., Rau A., and Chiolo I. Directed movement of heterochromatin DNA breaks requires nuclear actin filaments and myosin. Nature, 599, 54-60 (2018). *equal contribution.

Amaral N.*, Ryu T.*, Li X., and Chiolo I. Nuclear Dynamics of Heterochromatin Repair. Trends in Genetics, 2017. vol. 33(2) p.86-100. *equal contribution.

Ryu T., Bonner M., and Chiolo I. Cervantes and Quijote protect heterochromatin from aberrant recombination and lead the way to the nuclear periphery. Nucleus. 2016. vol. 7(5) p. 485-497.

Jain S., Mehta A., Sugawara N., Ryu T., and Haber JE. Sgs1 and Mph1 Enforce the Recombination Execution Checkpoint during DNA Double-Strand Break Repair in Saccharomyces cerevisiae Genetics, 2016. vol. 203(2) p.667-675.

Ryu T., Spatola B., Laetitia D., Bowlin K., Hopp H., Kunitake R., Karpen G., and Chiolo I. Heterochromatic breaks move to the nuclear periphery to continue recombinational repair. Nat.Cell. Biol. 2015. vol. 17 (11) p. 1401-1411.

Coic, E., Martin J., Ryu T., Tay S.Y., Kondev J., and Haber JE. Dynamics of homology searching during gene conversion in Saccharomyces cerevisiae revealed by donor competition. Genetics, 2011. 189(4) p. 1225-33.

Ryu T. Competition assay between gene conversion and single-stranded annealing in double strand break repair using Saccharomyces cerevisiae. Honors Thesis. Brandeis University, Department of Biology, 2011.