S. Dean Lee

RESEARCH

I am interested in understanding the relationship between genome organization and cellular functions--particularly how organizational variability across single cells could give rise to regulatory functions. To that end, I am developing imaging technologies to capture whole human chromosomes in super resolution using combinatorial sequential OligoSTORM as well as homolog-specific Oligopaints to distinguish paternal and maternal chromosomes using single nucleotide variants across the entire human genome. Together, these technologies provide a framework toward homolog-resolved, super-resolution imaging of the whole human genome.

PUBLICATIONS

Walking along chromosomes with super-resolution imaging, contact maps, and integrative modeling.

Guy Nir, Irene Farabella, Cynthia Pérez Estrada, Carl G. Ebeling, Brian J. Beliveau, Hiroshi M. Sasaki, S. Dean Lee, Son C. Nguyen, Ruth B. McCole, Shyamtanu Chattoraj, Jelena Erceg, Jumana AlHaj Abed, Nuno M. C. Martins, Huy Q. Nguyen, Mohammed A. Hannan, Sheikh Russell, Neva C. Durand, Suhas S. P. Rao, Jocelyn Y. Kishi, Paula Soler-Vila, Michele Di Pierro, José N. Onuchic, Steven P. Callahan, John M. Schreiner, Jeff A. Stuckey, Peng Yin, Erez Lieberman Aiden, Marc A. Marti-Renom, C.-ting Wu. PLOS Genetics, December 26, 2018 https://doi.org/10.1371/journal.pgen.1007872