Laura Breimann

RESEARCH

In the Wu lab, Laura is focusing on understanding whole-genome organisation with a focus on homologous chromosomes using diffraction-limited and super-resolution microscopy. To achieve this goal, she is also working on new imaging technologies and image analysis methods. 

PUBLICATIONS

[Google Scholar]

1. N. v. Kügelgen, K. Ludwik, S. Mendonsa, C. Roemer, E. Becher, L. Breimann, M. Strauch, T. Mari, S. Mongellaz, B. Zuckerman, F. Efendic, N. Grexa, A. Oliveras-Martinez, A. Woehler, M. Selbach, V. L. Bella, I. Ulitsky, and M. Chekulaeva, “Neuromuscular dysfunction in patient-derived fusr244rr–als ipsc model via axonal downregulation of neuromuscular junction proteins,” NAR Molecular Medicine, vol. 2, no. 2, p. ugaf005, 2025.

2. L. Breimann, E. Bahry, M. Zouinkhi, K. Kolyvanov, L. A. Street, S. Preibisch, and S. Ercan, “Analysis of developmental gene expression using smFISH and in silico staging of C. elegans embryos,” bioRxiv, p. 2024.05.15.594414, 2024

3. M. P. Smela, J. Adams, C. Ma, L. Breimann, U. Widocki, T. Shioda, and G. M. Church, “Induction of Meiosis from Human Pluripotent Stem Cells,” bioRxiv, p. 2024.05.31.596483, 2024.

4. J. Stein, M. Ericsson, M. Nofal, L. Magni, S. Aufmkolk, R. B. McMillan, L. Breimann, C. P. Herlihy, S. D. Lee, A. Willemin, J. Wohlmann, L. Arguedas-Jimenez, P. Yin, A. Pombo, G. M. Church, and C.-t. Wu, “Cryosectioning-enabled super-resolution microscopy for studying nuclear architecture at the single protein level,” bioRxiv, p. 2024.02.05.576943, 2024.

5. I. Loedige, A. Baranovskii, S. Mendonsa, S. Dantsuji, N. Popitsch, L. Breimann, N. Zerna, V. Cherepanov, M. Milek, S. Ameres, and M. Chekulaeva, “mRNA stability and m6A are major determinants of subcellular mRNA localization in neurons,” Molecular Cell, 2023.

6. Mendonsa, S.*, Kügelgen, N. von*, Dantsuji, S.*, Ron, M.*, Breimann, L., Baranovskii, A., Lödige, I., Kirchner, M., Fischer, M., Zerna, N., et al. (2023). Massively parallel identification of mRNA localization elements in primary cortical neurons. Nat Neurosci, 1–12. 10.1038/s41593-022-01243-x. 

7. Bahry, E.*, Breimann, L.*, Zouinkhi, M.*, Epstein, L., Kolyvanov, K., Mamrak, N., King, B., Long, X., Harrington, K.I.S., Lionnet, T., et al. (2022). RS-FISH: precise, interactive, fast, and scalable FISH spot detection. Nat Methods 19, 1563–1567. 10.1038/s41592-022-01669-y. 

8. L. Breimann*, A. K. Morao* , J. Kim, D. Sebastian Jimenez, N. Maryn, K. Bikkasani, M. J. Carrozza, S. E. Albritton, M. Kramer, L. A. Street, K. Cerimi, V.-F. Schumann, E. Bahry, S. Preibisch, A. Woehler, and S. Ercan, “The histone H4 lysine 20 demethylase DPY-21 regulates the dynamics of condensin DC binding,” Journal of Cell Science, 01 2022.

9. L. Breimann*, F. Preusser*, and S. Preibisch, “Light-microscopy methods in C. elegans research,” Current Opinion in Systems Biology, vol. 13, pp. 82 – 92, 02 2019.

10. M. L. Fortezza, G. Grigolon, A. Cosolo, A. Pindyurin, L. Breimann, H. Blum, B. v. Steensel, and A.-K. Classen, “DamID profiling of dynamic Polycomb-binding sites in Drosophila imaginal disc development and tumorigenesis,” Epigenetics & Chromatin, vol. 11, no. 1, p. 27, 2018.

* equal contribution